Guanidineacetic Acid

Other Trading Names:

  • Guanidineacetic acid

CAS Number: 352-97-6

HS Code: 29252000

Types of Packaging:

  • 25kg/ drum
Inquiry right-arrow $100.00
Availability: Out of stock
Guanidineacetic Acid


White crystalline powder

Purity (min)




Dry weight loss


Residue on ignition(as sulphated ash)




Ash content


Chemical Description

  • Guanidineacetic acid, also known as glycocyamine, is a derivative of glycine in which the hydrogen of the amino group is replaced by a guanidine group. It is a naturally occurring compound in vertebrates.
  • The molecular formula of guanidineacetic acid is C3H7N3O2, and its molecular weight is 117.11 g/mol. The compound consists of a glycine backbone with an additional guanidine group attached to the nitrogen atom.
  • Guanidineacetic acid is a white, crystalline powder that is soluble in water and slightly soluble in alcohol. It is commonly found in dietary supplements aimed at enhancing athletic performance and cognitive function.
  • In biological systems, guanidineacetic acid serves as a precursor to creatine. It is synthesized in the kidneys from glycine and arginine through the action of the enzyme glycine amidinotransferase.
  • After its synthesis, guanidineacetic acid is transported to the liver, where it undergoes methylation by the enzyme guanidinoacetate N-methyltransferase, converting it into creatine. Creatine then plays a crucial role in energy storage and transfer within muscle cells.
  • Guanidineacetic acid has been studied for its potential to improve muscle strength, reduce fatigue, and enhance overall physical performance. These effects are primarily due to its role in the biosynthesis of creatine, which is vital for ATP regeneration during high-intensity physical activities.
  • In addition to its role in creatine synthesis, guanidineacetic acid has been explored for its potential neuroprotective properties. Some research suggests that it may help in protecting neurons from oxidative stress and support cognitive functions.
  • Guanidineacetic acid exhibits zwitterionic properties, meaning it can carry both positive and negative charges at physiological pH. This characteristic impacts its solubility and interaction with other molecules in biological systems.
  • The chemical stability of guanidineacetic acid makes it a suitable candidate for various applications in the pharmaceutical and nutraceutical industries. It can be used in formulations intended to support muscle metabolism and cognitive health.
  • Safety studies on guanidineacetic acid indicate that it is generally well-tolerated when used at recommended dosages. However, excessive intake can lead to side effects such as gastrointestinal discomfort and altered renal function.
  • Research continues to explore the full range of benefits and potential applications of guanidineacetic acid, aiming to better understand its role in human health and its therapeutic potential in various conditions.
  • The commercial production of guanidineacetic acid involves the synthesis from glycine and cyanamide under controlled conditions, followed by purification processes to ensure high purity and quality of the final product.
  • Due to its importance in creatine synthesis, guanidineacetic acid remains a significant focus in the fields of sports nutrition and medical research, offering insights into how amino acid derivatives can influence physical and mental performance.
Write Your Own Review
You're reviewing:Guanidineacetic Acid

Quote Request Form

Guanidineacetic Acid